STUDIES OF THE ANTIDIURESIS OF QUIET STANDING: OBSERVATIONS UPON ELECTROLYTE AND ACID-BASE EXCRETION DURING SULFATE DIURESIS 1

Abstract

Quiet standing during the course of a sodium sulfate diuresis in 5 subjects produced the following changes: (a) an abrupt decrease in the renal excretion of Na and Cl, (b) little change in urine flow, creatinine clearance, or the excretion of sulfate, (c) an increase in the excretion of K and ammonium and a fall in urinary pH. Administration of Diamox prior to quiet standing prevented the increase in excretion of potassium and acid during quiet standing. Administration of Thiomerin prior to quiet standing blocked the increase in potassium excretion but did not prevent the formation of a more acid urine with an increase in the excretion of ammonium. The results suggest that under these circumstances both K and H ion may participate simultaneously in the reabsorption of Na by the renal tubules through an active process of ionic exchange.