Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes.
Open Access
- 1 September 1990
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 172 (3), 989-992
- https://doi.org/10.1084/jem.172.3.989
Abstract
Infection of astrocytes with Newcastle disease virus stimulated the production of 1,2-diacylglycerol, and resulted in the kinase-dependent expression of mRNAs encoding tumor necrosis factor (TNF), interferon .alpha. and .beta., and interleukin 6. The half-life of TNF mRNA was significantly decreased in the presence of protein kinase inhibitors H-7 and staurosporine, but not in the presence of HA1004. In contrast to the decay of TNF mRNA, the half-lives of other cytokine mRNAs were only minimally affected by the kinase inhibitors. These data indicated that the stability of TNF mRNA was regulated through a novel, kinase-dependent pathway.This publication has 13 references indexed in Scilit:
- Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.Proceedings of the National Academy of Sciences, 1989
- Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation PathwayScience, 1989
- Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulinNature, 1988
- Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.Journal of Biological Chemistry, 1988
- Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and TranslationScience, 1988
- Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.The Journal of Immunology, 1987
- Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulationCell, 1987
- Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinaseBiochemical and Biophysical Research Communications, 1986
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase CBiochemistry, 1984
- Two levels of regulation of beta-interferon gene expression in human cells.Proceedings of the National Academy of Sciences, 1983