Interferon‐γ activates the cleavage of double‐stranded RNA by bovine seminal ribonuclease
- 17 September 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 270 (1-2), 229-232
- https://doi.org/10.1016/0014-5793(90)81275-s
Abstract
Bovine seminal ribonuclease (BS‐RNase), a dimeric homologue of RNase A, cleaves both single‐ and double‐stranded RNA and inhibits the growth of tumor cells. Its catalytic activity against double‐stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon‐γ (IFN‐γ). Activation is seen with as little as 4–10 interferon units per assay. Enhancing the degradation of double‐stranded RNA, an intermediate in the growth cycle of many viruses, could contribute to IFN‐γ's ability to control cell growth and induce an antiviral state.Keywords
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