STUDY OF BOVINE PULMONARY RESPONSE TO PASTEURELLA-HAEMOLYTICA - PULMONARY MACROPHAGE RESPONSE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41 (7), 1008-1014
Abstract
A resistant state was produced in the bovine lung by exposing calves to an aerosolized mist of P. haemolytica. Verification of the resistant state was determined by an increase in clearance of P. haemolytica from lungs of exposed calves vs. lungs from non-exposed calves over 24 h. Bovine pulmonary macrophages isolated from lung washings of calves exposed to P. haemolytica and from lungs of non-exposed calves failed to phagocytize P. haemolytica in vitro. Whole serum, pulmonary immunoglobulin (Ig)A and IgG from exposed and non-exposed calves did not enhance phagocytosis as measured by 14C uptake or fluorescent antibody staining.