Chromosome 8 abnormalities as components of neoplastic and hematologic disorders

Abstract

Publications involving patients with any abnormality of chromosome 8 were reviewed in detail. For the time period involved, a total of 277 cases were found, including 74 instances of congenital aneuploidy, 130 instances of acquired aneuploidy, 38 instances of congenital rearrangements and 35 instances of acquired rearrangements. A total of 170 cases of neoplastic and hematologic disorders were included; 3 were associated with congenital aneuploidy, 2 with congenital rearrangements and the remaining 165 with acquired aberrations. The specific disorders ranged from sideroblastic anemia through chronic and acute leukemia to solid tumors. There appears to be a definite, though non-specific correlation between congenital or acquired chromosome 8 abnormalities and the development of certain types of neoplastic growth.