Chromosome Banding Patterns of 49 Cases of Chronic Myelocytic Leukemia

Abstract

To the Editor: Since the advent of Giemsa band analysis, a number of cytogenetic anomalies have been identified in the bone marrow of patients with chronic myelocytic leukemia. Our own series since 1973 includes 49 patients (17 female and 32 male) averaging 52 years of age. Forty had the Philadelphia chromosome (Ph¹), seven lacked it, and in the last two the Ph¹ was not discrete but "masked" by being translocated onto another chromosome. The Ph¹ chromosome (22q-) results, in general, from an interchange between the long arm (q) of chromosome 22 and the telomeric long arm area of . . .