Molecular analysis of the association of HLA-B53 and resistance to severe malaria
- 1 December 1992
- journal article
- Published by Springer Nature in Nature
- Vol. 360 (6403), 434-439
- https://doi.org/10.1038/360434a0
Abstract
The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.Keywords
This publication has 60 references indexed in Scilit:
- Immunity to the liver stage of malariaParasitology Today, 1991
- Common West African HLA antigens are associated with protection from severe malariaNature, 1991
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesNature, 1991
- Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35Human Immunology, 1991
- Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological diseaseNature, 1990
- Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb moleculeNature, 1990
- Polymorphism and malaria vaccinesParasitology Today, 1990
- Malaria and the major histocompatibility complexParasitology Today, 1989
- The real difficulties for malaria sporozoite vaccine development: nonresponsiveness and antigenic variationImmunology Today, 1988
- An HLA class I specific monoclonal antibody that fails to bind to all HLA-A antigensHuman Immunology, 1985