TESTICULAR FUNCTION IN POST PUBERTAL MALE PSEUDOHERMAPHRODITISM
- 1 November 1979
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 11 (5), 481-490
- https://doi.org/10.1111/j.1365-2265.1979.tb03100.x
Abstract
Testicular endocrine function was studied in twelve post pubertal patients with male pseudohermaphroditism and 46 XY chromosomal constitution. Patients were divided into three groups, four subjects who became feminized during puberty, five who became masculinized during puberty and three who were castrated before puberty. Serum dehydroepiandrosterone, progesterone, 17-hydroxyprogesterone, androstendione, testosterone, dihydrotestosterone, LH and FSH were determined by radioimmunoassay. Patients of the first group had the clinical characteristics of testicular feminization secondary to absence of the androgen receptor. One of the five patients of the second group had deficient testosterone secretion but no enzymatic defect could be demonstrated. One of the subjects castrated before puberty had a deficiency in 17,20-desmolase. Therefore, evidence of a failure of the fetal testes could be found in only two of the twelve patients studied.This publication has 13 references indexed in Scilit:
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