Detection of a restriction site polymorphism within the human ?-globin gene complex
- 1 February 1985
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 69 (2), 144-146
- https://doi.org/10.1007/bf00293285
Abstract
A mutant RsaI restriction endonuclease site of high frequency has been identified in individuals of German, Greek, Italian, and Turkish origin. The mutation was found within the α-globin gene complex and is located 0.7 kb 5′ to the α-globin gene. In individuals of central European origin 34 out of 58 chromosomes exhibited the α-gene linkage to the presence of the polymorphic site, and thus a preliminary estimate of the gene frequency for this allele would be 0.59. DNA analysis data of individuals derived from Mediterranean populations indicate a distribution of this polymorphic marker in similar frequencies.This publication has 14 references indexed in Scilit:
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