Neisseria meningitidis and Neisseria gonorrhoeae Bacteremia Associated with C6, C7, or C8 Deficiency

Abstract

Data from 24 previously described or newly diagnosed cases of homozygous deficiency of the 6th, 7th, or 8th components of complement [C] are summarized. Of 24 patients, 13 had at least 1 episode and usually 2 or more episodes of N. meningitidis or N. gonorrhoeae bacteremia or both. Deficiency of C6, C7 or C8 is a meaningful risk factor for repeated neisserial bacteremia; hemolytic C studies are indicated in patient who develop recurrent neisserial infections. When a person with C6, C7 or C8 deficiency is identified, family members should be studied.