Th1 and Th2 cells
- 1 January 2001
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Hematology
- Vol. 8 (1), 47-51
- https://doi.org/10.1097/00062752-200101000-00009
Abstract
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells. Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed.Keywords
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