Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel
- 1 September 1986
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 323 (6083), 36-39
- https://doi.org/10.1038/323036a0
Abstract
Osmotic stress can be used to estimate the internal volume change during the opening and closing of a voltage gated ionic channel. Mitochondrial voltage-dependent anion channels, from rat liver and from Neurospora, reconstituted into planar lipid bilayers show a change of 2 to 4 .times. 104 .ANG.3 in internal volume, a large change inconsistent with a blocking or local gating model but supporting models with major closure of the channel space.This publication has 22 references indexed in Scilit:
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