Human Proinsulin, VII. Synthesis of Two Protected Peptides Corresponding to the Sequences 1—45 and 46—86 of the Prohormone
- 1 January 1980
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 361 (1), 857-864
- https://doi.org/10.1515/bchm2.1980.361.1.857
Abstract
The synthesis of 2 protected large peptides 1-45, and 46-86 covering the entire amino acid sequence of human proinsulin is described. Peptide 1-45, was synthesized from 2 intermediate fragments 1-23 and 24-45 and purified by countercurrent distribution in dimethylformamide system (K = 0.5). Peptide 46-86 was synthesized from 2 intermediate fragments 46-70 and 71-86 and purified by countercurrent distribution in 2 solvent systems, the dimethylformamide system (K = 0.06), and the toluene system (K = 0.16).This publication has 10 references indexed in Scilit:
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