Ly-1 inducer and Ly-1,2 acceptor t cells in the feedback suppression circuit bear an I-J-subregion controlled determinant
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 11-11 (1), 549-557
- https://doi.org/10.1007/bf01567824
Abstract
An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same 1-J determinant. Since less than 10 percent of Ly-1 or Ly-1,2 T cells are killed by anti-I-J plus complement treatment, the I-J determinant demarcates functionally distinct subsets of both the Ly-1 and Ly-1,2 T-cell sets. This I-J determinant is not expressed on a detectable number of Ly-1 helper T cells which induce B lymphocytes to produce anti-sheep red cell antibody in tissue culture.This publication has 16 references indexed in Scilit:
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