Inhibition of Mononuclear Phagocyte Elongation, Migration, and Cellular Exudate Formation following Bordetella pertussis Vaccine Administration

Abstract

The effects of the i.v. administration of phase I B. pertussis vaccine (BPV) on several functions of murine peritoneal macrophages were examined. Macrophages obtained from mice on days 2 and 6 after BPV administration demonstrated a significant reduction in elongation and random migration activities in vitro. Mice injected i.v. with BPV 2 or 6 days prior to an i.p. challenge with proteose peptone broth exhibited a reduced peritoneal cellular exudate response. The component of BPV responsible for all 3 activities was labile to heating at 80.degree. C for 30 min. The systemic administration of BPV apparently alters peritoneal macrophage function; the same component of BPV seemingly is responsible for these alterations.