Comparative in-vitro activity of five fluoroquinolones against mycobacteria
- 1 May 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 19 (5), 605-609
- https://doi.org/10.1093/jac/19.5.605
Abstract
Fifty distinct strains of mycobacteria were investigated to determine their in-vitro susceptibility to five new fluoroquinolones (norfloxacin, pefloxacin, ofloxacin, enoxacin and ciprofloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentrations (MIC) of 1.25 mg/l or less to all strains of Mycobacterium tuberculosis, M. bovis, M. xenopi, M. kansasii and BCG tested. All agents showed little activity against M. malmoense and M. avium-intracellulare complex with MIC values of greater than 2.5 mg/l.Keywords
This publication has 8 references indexed in Scilit:
- In-vitro susceptibility of mycobacteria to ciprofloxacinJournal of Antimicrobial Chemotherapy, 1985
- THERAPEUTIC EFFECT OF A NEW ANTIBACTERIAL SUBSTANCE OFLOXACIN (DL8280) ON PULMONARY TUBERCULOSISPublished by Elsevier ,1985
- In-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agentsJournal of Antimicrobial Chemotherapy, 1985
- In vitro activity of CI-919 (AT-2266), an oral antipseudomonal compoundAntimicrobial Agents and Chemotherapy, 1983
- In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agentsAntimicrobial Agents and Chemotherapy, 1983
- In vitro and in vivo activity of DL-8280, a new oxazine derivativeAntimicrobial Agents and Chemotherapy, 1982
- STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE QUINOLONE GROUP - ANTI-BACTERIAL ACTIVITY OF 2 NEW COMPOUNDS1981
- Mycobacterium malmoense sp. nov.International Journal of Systematic and Evolutionary Microbiology, 1977