Biochemical characterization of alien H-2 antigens expressed on a methylcholanthrene-induced tumor.
- 1 March 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (3), 1415-1419
- https://doi.org/10.1073/pnas.76.3.1415
Abstract
A methylcholanthrene-induced tumor [C-1] of BALB/c (H-2d) origin expresses H-2 antigens [Ag] normally associated with the H-2k haplotype. The molecules expressing the alien Ag were partially purified and were distinct from molecules expressing normal H-2d Ag. Like normal H-2 Ag, the alien Ag have a MW of 48,000, are glycoproteins and are noncovalently bound to .beta.2-microglobulin. The alien Ag differ from normal H-2 Ag in their susceptibility to papain digestion, behavior during gel filtration and overall stability. Possible mechanisms accounting for the expression of the alien Ag are discussed.This publication has 28 references indexed in Scilit:
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