Renal Response to Nonshocking Hemorrhage

Abstract

The role of the autonomic nervous system in renal response to limited, nonshocking hemorrhage was studied in anesthetized dogs. Autonomic blockade with hexamethonium, and unilateral renal denervation failed to prevent the reduced excretion of water, Na and Cl which was induced by hemorrhage, although the arterial blood pressure was well maintained and although the mean changes of filtered sodium (FNa) and of renal plasma flow (ERPF) were not significant. Retransfusion of shed blood restored renal excretory functions despite: a) autonomic blockade, b) renal denervation, c) the maintenance of constant arterial blood pressure, and d) insignificant mean changes of FNa and ERPF. These findings are discussed in relation to possible mechanisms of the renal response to withdrawal of blood from the effective circulation.