Influence of Thrombin on Rate of Prothrombin Conversion

Abstract

Both antihemophilic factor and plasma accelerator-globulin are necessary to obtain complete conversion of prothrombin in the presence of a BaSO4-eluate preparation from serum, phospholipid-thromboplastin and CaCl2. In the presence of traces of thrombin conversion of prothrombin to thrombin becomes greatly accelerated. Results indicate that thrombin greatly accelerates formation of a prothrombin-conversion factor. This influence of thrombin appears to be mediated through its activating effect on plasma accelerator-globulin and, perhaps, also on the antihemophilic factor.