Effects of Some Metabolic Analogs on Growth of Mumps and Influenza Viruses in Tissue Cultures.

Abstract

The vitamin analogs oxythiamine and desoxypyridoxine inhibit the multiplication of mumps and influenza (PR8) viruses in tissue cultures at concns. shown to be without observable toxic effects on the tissue itself. Other analogs tested, including pyridine-3-sulfonic acid, salicyl-beta-alanide, 2-amino-4-hydroxy-6-formylpterine, 2,6-diaminopurine, 8-azaguanine, and beta-2-thienylalanine, demonstrated no significant inhibitory effects on the growth of these viruses under the conditions of these expts.