Fatal Transfusion Reactions from Massive Bacterial Contamination of Blood

Abstract

THE sterility of stored whole blood depends on three factors: aseptic technic, a sterile system for collection and storage and immediate, continuous refrigeration. These measures are highly effective for preserving blood in a relatively sterile state. Nevertheless, under certain circumstances, gross bacterial contamination of stored blood can occur. Although the essential features of accidents resulting from the administration of contaminated Wood are mentioned by Whitby,¹ detailed descriptions are not available.The administration of contaminated blood produces a characteristic clinical syndrome that may be incorrectly interpreted. There is reason to believe that transfusion reactions due to bacterial contamination have occurred more . . .