Thyroid Function in Patients with Aspermiogenesis and Testicular Tubular Sclerosis

Abstract

IN 1942 Klinefelter et al.¹ described a syndrome of micro-orchidism, azoospermia, hyalinization of seminiferous tubules, elevated urinary follicle-stimulating hormone (FSH) and gynecomastia. Since then it has become apparent from numerous reports that Klinefelter's syndrome may be variously manifested but at least consists of micro-orchidism, oligospermia, hyalinization of seminiferous tubules² (even though occasional areas of spermatogenesis may be seen^{3 4 5 6 7}), an apparent increase in Leydig cells and an elevated FSH level.^{1 , 8 , 9} There may or may not be gynecomastia,^{2 , 7} the body habitus may range from the eunuchoid to the male type,^{5 6 7 , 10} the I.Q. may be normal to subnormal,^{10 11 12 13 14 15} and the chromosomal pattern . . .