GAMETOGENIC FAILURE WITH HIGH URINARY GONADOTROPIN (FSH)

Abstract

THE existence of a second testicular substance with hormonal activity was suggested by Mottram and Cramer (1) in 1923 when it was shown that castration cells appeared in the pituitaries of adult male rats that had received roentgen ray treatment to the testes. The dosage was such that the Ley dig cells were preserved and the secondary sexual organs, namely the seminal vesicles and the prostate which they support, were maintained but the germinal epithelium of the seminiferous tubules was destroyed. They concluded: “The observations show that the two component tissues of the testis, the spermatogenetic tissue and the interstitial tissue, have two distinct and independent effects on the organism, and that of these two effects that of the interstitial cells is the more profound one.” Evans (2) in 1929 showed by implantation experiments that there was more gonadotropic hormone in the pituitary glands of cryptorchid animals than in the pituitary glands of normal animals.