Patent Update Oncologic, Endocrine & Metabolic: Oncologic, Endocrine & Metabolic: Recent advances in the field of matrix metalloproteinase inhibitors
- 1 December 1996
- journal article
- Published by Taylor & Francis in Expert Opinion on Therapeutic Patents
- Vol. 6 (12), 1305-1315
- https://doi.org/10.1517/13543776.6.12.1305
Abstract
Matrix metalloproteinases (MMPs) are involved in the normal processes of tissue remodelling and repair, but have increasingly been implicated in a range of disease states where they are over-expressed. This review summarises developments in the design and clinical evaluation of synthetic MMP inhibitors since the subject was last covered in this journal in 1995.Keywords
This publication has 19 references indexed in Scilit:
- Rapid synthesis of novel dipeptide inhibitors of human collagenase and gelatinase using solid phase chemistryBioorganic & Medicinal Chemistry Letters, 1996
- Inhibitors of MMP-1: an examination of P1′ Cα gem-disubstitution in the N-carboxyalkylamine and glutaramide carboxylate seriesBioorganic & Medicinal Chemistry Letters, 1996
- Orally active inhibitors of stromelysin-1 (MMP-3)Bioorganic & Medicinal Chemistry Letters, 1996
- Potent matrix metalloproteinase inhibitors: Amino-carboxylate compounds containing modifications of the P1 residueBioorganic & Medicinal Chemistry Letters, 1996
- Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptidesBioorganic & Medicinal Chemistry Letters, 1996
- Probing the P3′ pocket of stromelysin with piperazic acid analogsBioorganic & Medicinal Chemistry Letters, 1995
- Review Oncologic, Endocrine & Metabolic: Recent developments in matrix metalloproteinase inhibitorsExpert Opinion on Therapeutic Patents, 1995
- Inhibition of matrix metalloproteinases by N-carboxyalkyl dipeptides: Enhanced potency and selectivity with substituted P1′ homophenylalaninesBioorganic & Medicinal Chemistry Letters, 1995
- Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1′ heteroatom based modificationsBioorganic & Medicinal Chemistry Letters, 1995
- Synthesis and Structure-Activity Relationships of Gelatinase Inhibitors Derived from Matlystatins.CHEMICAL & PHARMACEUTICAL BULLETIN, 1995