Increased Excretion of Urinary N-Acetyl-β-Glucosaminidase in Essential Hypertension and Its Decline with Antihypertensive Therapy

Abstract
The urinary excretion of N-acetyl-β-glucosaminidase (NAG) is increased in patients whose renal function is impaired by a variety of kidney diseases, and may provide an index of renal injury. To assess its role in essential hypertension, we measured urinary levels of NAG in 80 subjects with essential hypertension (and no evidence of renal disease) and 30 normal controls. NAG values were measured before therapy and after 3 and 12 months of treatment with diuretics.