Studies on ali-esterases. 6. Selective inhibitors of the esterases of brain and saprophytic mycobacteria
- 1 February 1957
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 65 (2), 232-241
- https://doi.org/10.1042/bj0650232
Abstract
The ali-esterase activity of rat brain, Mycobacterium phlei and 3 other strains of Mycobacterium was determined manometrically using tributyrin as sub-strate following a 30 minute preincubation period at 37[degree]C with one of a series of 49 inhibitors, chiefly organophosphorous compounds and carbamate esters. Residual cholinesterase activity was measured using [beta]-methylcholine as substrate. Although many of the substances investigated were poor inhibitors of true cholinesterase some were highly effective against ali-esterases. No compound was found that would act as a selective inhibitor of the all esterases without inhibiting cholin-esterases.Keywords
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