Sites of Production of Primate Serum Proteins Associated with the Complement System.

Abstract

Various human and monkey tissues, including liver, spleen, bone marrow and lung were found to incorporate C14-amino acids into 11S globulin (C[image]1q) in vitro. A comparison with previous studies on [beta]1C (C[image]3) and [beta]1E (C[image]4) production revealed a striking similarity in the sites of synthesis of these 3 proteins. Primate macrophages isolated from peritoneal exudates or lungs were particularly active in the synthesis of [beta]1C, [beta]1E, and 11S globulin. Macrophages of various species appear to constitute a major site of production of several complement components.