Spontaneous excretion of d-alanine in urine in mutant mice lacking d-amino-acid oxidase
- 30 June 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 261 (1), 285-287
- https://doi.org/10.1042/bj2610285
Abstract
Urine from mutant mice lacking D-amino-acid oxidase contained a large amount of alanine compared with that from normal mice. Urinary alanine of the mutant mice was sensitive to D-amino-acid oxidase. H.p.l.c. showed that about 94% of the urinary alanine had the D-configuration. These results suggest that D-amino-acid oxidase functions to decompose D-amino acid(s) in normal mice.This publication has 14 references indexed in Scilit:
- Involvement of d-amino acid oxidase in elimination of free d-amino acids in miceBiochemical Journal, 1989
- Excessive urinary excretion of methionine in mutant mice lacking d-amino-acid oxidase activityMetabolism, 1988
- Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouseBiochimica et Biophysica Acta (BBA) - General Subjects, 1988
- Molecular cloning and sequence analysis of cDNA encoding human kidney D‐amino acid oxidaseFEBS Letters, 1988
- Free d-amino acids in human plasma in relation to senescence and renal diseasesClinical Science, 1987
- Molecular cloning and sequence analysis of cDNAs encoding porcine kidney D-amino acid oxidaseBiochemistry, 1987
- Brain and Kidney d-Amino Acid Oxidases Are Coded by a Single Gene in the MouseJournal of Neurochemistry, 1984
- The primary structure of D-amino acid oxidase from pig kidney. II. Isolation and sequence of overlap peptides and the complete sequence.Journal of Biological Chemistry, 1982
- ALANINE - CYCLOSERINE ANTAGONISM .6. DEMONSTRATION OF D-ALANINE IN SERUM OF GUINEA PIGS AND MICE1965
- Metabolism of amino-acidsBiochemical Journal, 1935