Repair of radiation-induced lethal and mutational damage in chinese hamster cells in vitro.

Abstract

The ability of Chinese hamster hai cells to repair damage related to cell death and mutational change induced by X-rays was studied by using a sensitive forward mutation system from prototrophic CH-hai Cl 23 cells to auxotrophs. The results obtained from the dose rate and split-dose experiments suggest that Chinese hamster hai cells have repair mechanisms for the sublethal and mutational damage induced by X-rays and that these mechanisms act in common for repair of both types of damage. In addition, we also found that these cells have repair abilities for lethal and mutational damage induced by a potentially lethal dose of radiation.