The Effects of Diamox(R) on the Uterine Response of Estrogen Treated Rats.

Abstract

Diamox (40 mg) postpones the peak of water imbibition in the uterus of estradiol treated immature rats from the 6th to the 12th hour. It is, however, incapable of blocking the normal growth response occurring at 30 hours. Daily doses of 40 and 60 mg of Diamox given concurrently with 5 [mu]g of estrone per day for 3 days to castrated adults did not alter the percentage of water in the uterine tissues from that reported for the estrogen alone. It is suggested that imbibition of water and the proliferative phase observed in the uterus under estrogen stimulation represent independent reactions.