Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells
- 1 November 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 312 (5993), 418-423
- https://doi.org/10.1038/312418a0
Abstract
Most IgH chain gene diversity (D) segments carry their own 5'' transcriptional promoter element. Transcription of rearrangements which use H chain D and joining (J) segments in B lymphoid cells [for mice] ultimately leads to the production of a D.mu. mRNA which contains the DJH segments linked to the .mu. H chain constant region. If the D is joined to the JH segment in the appropriate translational reading frame, this D.mu. mRNA is translated to yield a short D.mu. protein with a variable DJH N-terminus.This publication has 42 references indexed in Scilit:
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