(NZW x BXSB)F1 mouse. A new animal model of idiopathic thrombocytopenic purpura.
Open Access
- 1 June 1988
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 167 (6), 2017-2022
- https://doi.org/10.1084/jem.167.6.2017
Abstract
A decrease in thrombocyte count was observed in (NZW x BXSB)F1 (W/B F1) mice at the age of greater than 5 mo, whereas megakaryocyte counts were found to increase in such mice. FACS analyses revealed the presence of both platelet-associated antibodies (PAA) and circulating antiplatelet antibodies. There is a correlation between the presence of these antibodies and the degree of thrombocytopenia. The transplantation of normal bone marrow cells from BALB/c nu/nu mice to W/B F1 mice was found to have preventative and curative effects on thrombocytopenia; the mice showed normal platelet counts and no evidence of circulating antiplatelet antibodies. These results indicate that thrombocytopenia in W/B F1 mice is due to the presence of antibodies to platelets. We therefore think that W/B F1 mice serve as a useful animal model of idiopathic thrombocytopenic purpura (ITP) not only for elucidating the mechanism of the development of antiplatelet antibodies, but also for characterizing autoantibodies to platelets.This publication has 9 references indexed in Scilit:
- Treatment of type 1 diabetes mellitus in non-obese diabetic mice by transplantation of allogeneic bone marrow and pancreatic tissue.Proceedings of the National Academy of Sciences, 1987
- Effects of EDTA on the membrane glycoproteins IIB-IIIa complex — analysis using flow cytometryThrombosis Research, 1987
- Complement-Mediated Autoimmune ThrombocytopeniaNew England Journal of Medicine, 1987
- Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation.Proceedings of the National Academy of Sciences, 1985
- Rationale for bone marrow transplantation in the treatment of autoimmune diseases.Proceedings of the National Academy of Sciences, 1985
- TRANSFER OF RENOVASCULAR HYPERTENSION AND CORONARY HEART-DISEASE BY LYMPHOID-CELLS FROM SLE-PRONE MICE1984
- (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction.The Journal of Experimental Medicine, 1981
- Chronic Idiopathic Thrombocytopenic PurpuraNew England Journal of Medicine, 1981
- Autoimmune Thrombocytopenia: Detection of Platelet Autoantibodies with the Suspension Immunofluorescence TestBritish Journal of Haematology, 1980