Reversible Inhibition of the Beat in Heart Fragment Tissue Cultures by Desoxycorticosterone
- 1 November 1950
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 75 (2), 355-357
- https://doi.org/10.3181/00379727-75-18196
Abstract
Desoxycorticosterone (DOC) at 0.01-0.05 mg./ml. reversibly stops the pulsation of hearts of 9-to 11-day chick embryos or of newborn or fetal mice in tissue culture. The inhibition can be removed by serum but not by cortisone, and is more effective in the absence of K. DOC acetate does not affect the pulsation. DOC and cortisone and their acetates have no influence on K inhibition of the heart. Epinephrine will almost completely counteract K inhibition but revives only a few DOC-poisoned fragments.Keywords
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