STRUCTURAL STUDIES ON INDUCED ANTIBODIES WITH DEFINED IDIOTYPIC SPECIFICITIES .5. COMPLETE AMINO-ACID SEQUENCE OF LIGHT CHAIN VARIABLE REGIONS OF ANTI-PARA-AZOPHENYLARSONATE ANTIBODIES FROM A-J MICE BEARING A CROSS-REACTIVE IDIOTYPE
- 1 January 1977
- journal article
- research article
- Vol. 119 (3), 993-999
Abstract
The complete amino acid sequence of the variable regions of L chains derived from anti-p-azophenylarsonate antibodies from A/J mice bearing a cross-reactive idiotype is reported. At least 2 and probably more than 3 distinct L chains are associated with this idiotypically characterized antibody. The antibodies have several differences in their framework structures but all 3 L chain hypervariable regions evidently have a homogeneous sequence. The data are discussed in relation to the various theories of antibody diversity. Hypervariable regions, idiotypic determinants and the antibody-combining site involve, to a large extent, the same molecular structures.This publication has 4 references indexed in Scilit:
- Frequency of occurrence of idiotypes associated with anti-p-azophenylarsonate antibodies arising in mice immunologically suppressed with respect to a cross-reactive idiotype.The Journal of Experimental Medicine, 1977
- Demonstration of an idiotypic antigen on a monoclonal cold agglutinin and on its isolated heavy and light chains.Proceedings of the National Academy of Sciences, 1976
- STRUCTURAL STUDIES ON INDUCED ANTIBODIES WITH DEFINED IDIOTYPIC SPECIFICITIES .3. N-TERMINAL AMINO-ACID SEQUENCE OF HEAVY AND LIGHT-CHAINS OF MOUSE ANTI-STREPTOCOCCAL ANTIBODIES - A5A, S8, AND S1171976
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