Mammalian Sirtuins: Biological Insights and Disease Relevance
Top Cited Papers
- 1 January 2010
- journal article
- review article
- Published by Annual Reviews in Annual Review Of Pathology-Mechanisms Of Disease
- Vol. 5 (1), 253-295
- https://doi.org/10.1146/annurev.pathol.4.110807.092250
Abstract
Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative ...Keywords
This publication has 288 references indexed in Scilit:
- The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their ImportanceCell Biochemistry and Biophysics, 2009
- Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3Protein Science, 2009
- Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant MiceCancer Cell, 2008
- SIRT1 Regulates Circadian Clock Gene Expression through PER2 DeacetylationCell, 2008
- p53 Activation: A Case against SirCancer Cell, 2008
- Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 ActivatorCancer Cell, 2008
- Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-agingAgeing Research Reviews, 2007
- Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell SurvivalCell, 2007
- FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell HomeostasisCell, 2007
- Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight IndividualsJAMA, 2006