The assessment of aspirin resistance by using light transmission and multiple electrode aggregometry
- 11 January 2011
- journal article
- Published by Wiley in International Journal of Laboratory Hematology
- Vol. 33 (3), 305-309
- https://doi.org/10.1111/j.1751-553x.2010.01286.x
Abstract
The issues related to aspirin [acetylsalicylic acid (ASA)] resistance are still under debate. Depending on the method of assessment and studied patients, the prevalence of ASA resistance is rather heterogeneous, ranging from 5% to 45%. The method most commonly used for assessing platelet function is their aggregation. ASA irreversibly inhibits cyclooxygenase-1 (COX-1) by acetylation. This study aimed to compare light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA) for the measurement of ASA resistance, using arachidonic acid as an inducer of the reaction. The study comprised 101 patients with stable ischemic heart disease taking a daily dose of 100 mg of ASA. The rates of ASA resistance were 22.22% and 21.21% as detected by LTA and MEA, respectively. The two methods were statistically compared using Spearman's nonparametric correlation analysis, with a positive significant correlation (P=0.01) and medium positive dependence between the methods (r=0.0539). If ASA resistance is detected by laboratory tests, replacement of ASA or its combination with other antiplatelet drugs as well as increased dosage may be considered.Keywords
This publication has 14 references indexed in Scilit:
- Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTHJournal of Thrombosis and Haemostasis, 2009
- Aspirin for the Prevention of Cardiovascular Events in Patients With Peripheral Artery DiseaseJAMA, 2009
- Aspirin noncompliance is the major cause of “aspirin resistance” in patients undergoing coronary stentingAmerican Heart Journal, 2009
- Response to aspirin in healthy individualsThrombosis and Haemostasis, 2009
- Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessaryJournal of Thrombosis and Haemostasis, 2008
- Platelet Activation and AtherothrombosisNew England Journal of Medicine, 2007
- Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet countHaematologica, 2007
- Prevalence of persistent platelet reactivity despite use of aspirin: A systematic reviewAmerican Heart Journal, 2007
- Aspirin resistanceThe Lancet, 2006
- Influence of blood collection techniques on platelet functionPlatelets, 2004