Reaction of 1-naphthylhydroxylamine with calf thymus deoxyribonucleic acid. Isolation and synthesis of N-(guanin-C8-yl)-1-naphthylamine.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 29 (9), 2730-2732
- https://doi.org/10.1248/cpb.29.2730
Abstract
A possible activated form of 1-naphthylamine, N-hydroxy-1-naphthylamine, reacted with C8-position of guanine in DNA. Hydrolysis of the modified DNA with nuclease and acid gave N-(guanin-C8-yl)-1-naphthylamine as a modified base. The C8-position of guanine seems to be a common site of attack on DNA by activated muta-carcinogenic aromatic amines.This publication has 3 references indexed in Scilit:
- Structural identification of a modified base in DNA covalently bound with mutagenic 3-amino-1-methyl-5H-pyrido[4,3-b]indole.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979
- GUANYL O-6-ARYLAMINATION AND O-6-ARYLATION OF DNA BY CARCINOGEN N-HYDROXY-1-NAPHTHYLAMINE1978
- HEPATIC MICROSOMAL N-GLUCURONIDATION AND NUCLEIC-ACID BINDING OF N-HYDROXY ARYLAMINES IN RELATION TO URINARY-BLADDER CARCINOGENESIS1977