Serum androgens and sex hormone binding globulin in obese Pima Indian females
- 1 August 1981
- journal article
- research article
- Published by Wiley in American Journal of Physical Anthropology
- Vol. 55 (4), 491-496
- https://doi.org/10.1002/ajpa.1330550410
Abstract
Levels of serum androgens and sex hormone binding globulin (SHBG) were measured in 20 obese Pima Indian females aged 19–44 and compared with those of normal‐weight Caucasians aged 20–46. The Pima exhibited significantly decreased SHBG compared to Caucasians, but a strong effect of age on androgen levels rendered mean comparisons useless. Androstenedione (A) and dehydroepiandrosterone‐sulfate (DHEA‐S) decreased significantly, and testosterone (T) declined slightly with age in the Pima, whereas these androgens showed no significant decreases in Caucasians for this age range. A possible relationship of androgens to the Pima female's propensity for android obesity as well as possible effects of obesity on SHBG, androgens, and aging is discussed.Keywords
This publication has 26 references indexed in Scilit:
- Endocrine-Environment Interaction in Human VariabilityAnnual Review of Anthropology, 1981
- ABNORMAL SEX STEROID SECRETION AND BINDING IN MASSIVELY OBESE WOMENClinical Endocrinology, 1980
- Comparison of androgenic effects on food intake and body weight in adult ratsPhysiology & Behavior, 1980
- Development of Lithogenic Bile during Puberty in Pima IndiansNew England Journal of Medicine, 1979
- SEPARATE ROLES OF ANDROGEN AND OESTROGEN IN THE MANIPULATION OF GROWTH AND EFFICIENCY OF FOOD UTILIZATION IN FEMALE RATSJournal of Endocrinology, 1979
- Dehydroepiandrosterone sulfate in plasma: hydrolysis, extraction and radioimmunoassaySteroids, 1976
- A radioimmunoassay for plasma testosteroneSteroids, 1970
- Alteration of Cholesterol Metabolism Induced by Anabolic Steroid, Oxandrolone, Administration to RatsEndocrinologia Japonica, 1970
- Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone.JCI Insight, 1966
- Obesity and the Aging of the Human Adrenal CortexGerontologia Clinica, 1966