METABOLISM OF RAT HEART SLICES, WITH SPECIAL REFERENCE TO EFFECTS OF TEMPERATURE AND ANOXIA

Abstract

Values are given for QO2, anaerobic glycolysis and aerobic lactic acid production of rat heart ventricular slices with glucose substrate. The QO2 was detd. over the temp. range 10[degree]-42.5[degree]C. The optimum temp. was 37.7[degree]C. Over the range 10[degree]-37[degree]C log QO2 was a linear function of log temp. in [degree]C. The QO2 of heart slices was decreased by exposure in vitro to complete anoxia for periods of from 2.5- 40 min. Exposure for 20 min. to partial anoxia varying from 5-50% O2 also decreased the rate of O2 consumption subsequently detd. in 100% O2.