DIETARY AND DOSAGE FACTORS AFFECTING THYROXINE INHIBITION OF ESTROGEN-INDUCED LIPEMIA IN THE CHICK

Abstract

Admn. of thyroxine suppresses the marked hyperlipemia induced in young chicks by treatment with estradiol benzoate and the degree of suppression is proportional to the dosage of thyroxine. This suppression of the lipemia is not accompanied by any interference with the oviduct-growth effect of the admd. estrogen. Oral admn. of an excess of B-complex factors does not reverse the thyroxine inhibition of the lipemia, suggesting that the effect is not due to a thyrotoxic depletion of any of these factors. The estrogen-induced increment in plasma biotin and fat-soluble factor (i.e., F.S.F. of Trager) is also suppressed by thyroxine.