Nalidixic Acid-Direct Compression Excipients, Preformulation Stability Screening Using Differential Scanning Calorimetry
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 10 (3), 491-504
- https://doi.org/10.3109/03639048409041402
Abstract
Differential scanning calorimetry was used as a screening technique for assessing the compatibility of nalidixic acid with some of the direct compression excipients. Nalidixic acid was found to be compatible with Brownex sugar, sorbitol, mannitol and granular mannitol, while incompatible with Cab-0-Sil, Di-Pac, Emdex and dicalcium phosphate dihydrate. It appears that stearic acid and L-(-)-leucine can be used as lubricants in formulations containing nalidixic acid while magnesium stearate cannot.This publication has 4 references indexed in Scilit:
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