Actions of Reserpine and Chlorpromazine Hydrochloride on Rat Brain Oxidative Phosphorylation and Adenosinetriphosphatase.
- 1 March 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 91 (3), 493-497
- https://doi.org/10.3181/00379727-91-22304
Abstract
Oxidative phosphorylation in rat brain homogenates was depressed by 2.5 x 10-4 [image] or more chlorpromazine and slightly decreased by 25 and 50 [mu]g/ml reserpine. Reserpine depressed oxidative phosphorylation more markedly in the presence of chlorpromazine. In vivo chlorpromazine (10 mg/kg) slightly increased O2 uptake. ATPase was slightly depressed by chlorpromazine but not by reserpine.Keywords
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