EFFECTS OF THE RECTAL ADMINISTRATION OF DIAZEPAM
- 1 June 1985
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 57 (6), 578-580
- https://doi.org/10.1093/bja/57.6.578
Abstract
Diazepam 1 mg/kg body weight was administered rectally to 14 children (11-22.5 kg) before minor surgery under general anesthesia. Administration in solution (n = 7) resulted in a rapid increase in serum concentrations which were maintained for 8 h. Administration by suppository (n = 7) resulted in significantly lower serum concentrations at 10 and 20 min, but higher concentrations at 2 h. At other intervals the concentrations did not differ from those reached after administration of diazepam in rectal solution. A solution should be used when rectal diazepam is used for premedication in children.This publication has 4 references indexed in Scilit:
- DIAZEPAM IN RECTAL SOLUTION AS PREMEDICATION IN CHILDREN, WITH SPECIAL REFERENCE TO SERUM CONCENTRATIONSBritish Journal of Anaesthesia, 1981
- Biopharmaceutics of rectal administration of drugs in man IX. Comparative biopharmaceutics of diazepam after single rectal, oral, intramuscular and intravenous administration in manInternational Journal of Pharmaceutics, 1980
- Absorption of Diazepam in Man Following Rectal and Parenteral AdministrationActa Pharmacologica et Toxicologica, 1979
- PLASMA‐DIAZEPAM IN INFANTS AFTER RECTAL ADMINISTRATION IN SOLUTION AND BY SUPPOSITORYActa Paediatrica, 1977