PLASMA‐DIAZEPAM IN INFANTS AFTER RECTAL ADMINISTRATION IN SOLUTION AND BY SUPPOSITORY

Abstract

Twenty infants aged 1-2 yr who had previously had 1 attack of febrile convulsions were randomly given a single dose of diazepam rectally, as a solution (0.7 mg/kg) or by suppository (5 mg). Plasma-diazepam levels were determined repeatedly during the 1st h using gas chromatography. Rectal administration in solution resulted in anticonvulsant plasma values within 4 .+-. 1 min. Similar plasma levels were obtained only after 20-30 min in the group treated with suppositories. Diazepam in solution given rectally may be useful in acute treatment of febrile convulsions, while suppository treatment seems of little value. Diazepam in solution given rectally seems suitable for use at home in case of recurrent febrile convulsions. This treatment cannot be recommended until the anticonvulsant effect and side-effects have been further elucidated.