Jumping translocation in a phenotypically normal female
- 1 March 1996
- journal article
- case report
- Published by Wiley in Clinical Genetics
- Vol. 49 (3), 156-159
- https://doi.org/10.1111/j.1399-0004.1996.tb03276.x
Abstract
"Jumping translocation" jt refers to a rare type of chromosome mosaic, in which the same portion of a (donor) chromosome is translocated to different (recipient) chromosome sites. Jt have mainly been observed in lymphocyte cultures of patients with hematologic malignancies. We report a phenotypically normal female carrying a mosaic of two cell lines with the Xq26-qter segment translocated to the short arm of chromosomes 15 or 21 in peripheral blood lymphocytes. In skin fibroblasts, only the X/21 translocation was detected. We speculate that recombination between homologous repetitive sequences on non-homologous human acrocentrics may be the cause of such chromosomal rearrangements.Keywords
This publication has 7 references indexed in Scilit:
- [3]Simple and nonisotopic methods to detect unknown gene mutations in nucleic acidsPublished by Elsevier ,1996
- Jumping translocation in a newborn boy with dup (4q) and severe hydrops fetalisAmerican Journal of Medical Genetics, 1994
- Jumping translocations of 1q in Burkitt lymphoma and acute nonlymphocytic leukemiaCancer Genetics and Cytogenetics, 1993
- Moving satellites and unstable chromosome translocations: Clinical and cytogenetic implicationsAmerican Journal of Medical Genetics, 1993
- Jumping translocations originate clonal rearrangements in SV40‐transformed human fibroblastsInternational Journal of Cancer, 1992
- Methylation patterns at the hypervariable X-chromosome locus DXS255 (M27β): Correlation with X-inactivation statusGenomics, 1990
- Telomeric association of chromosomes in B-cell lymphoid leukemiaHuman Genetics, 1984