Nanoemulsions: formation, properties and applications
Top Cited Papers
Open Access
- 23 February 2016
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Soft Matter
- Vol. 12 (11), 2826-2841
- https://doi.org/10.1039/c5sm02958a
Abstract
Nanoemulsions are kinetically stable liquid-in-liquid dispersions with droplet sizes on the order of 100 nm. Their small size leads to useful properties such as high surface area per unit volume, robust stability, optically transparent appearance, and tunable rheology. Nanoemulsions are finding application in diverse areas such as drug delivery, food, cosmetics, pharmaceuticals, and material synthesis. Additionally, they serve as model systems to understand nanoscale colloidal dispersions. High and low energy methods are used to prepare nanoemulsions, including high pressure homogenization, ultrasonication, phase inversion temperature and emulsion inversion point, as well as recently developed approaches such as bubble bursting method. In this review article, we summarize the major methods to prepare nanoemulsions, theories to predict droplet size, physical conditions and chemical additives which affect droplet stability, and recent applications.Keywords
This publication has 113 references indexed in Scilit:
- Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversionJournal of Colloid and Interface Science, 2012
- Nanoemulsions versus microemulsions: terminology, differences, and similaritiesSoft Matter, 2011
- Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsionsJournal of Controlled Release, 2011
- Multifunctional Nanoemulsion Platform for Imaging Guided Therapy Evaluated in Experimental CancerACS Nano, 2011
- Food-grade microemulsions, nanoemulsions and emulsions: Fabrication from sucrose monopalmitate & lemon oilFood Hydrocolloids, 2011
- How To Prepare and Stabilize Very Small NanoemulsionsLangmuir, 2011
- Time-Dependent Nanoemulsion Droplet Size Reduction By Evaporative RipeningThe Journal of Physical Chemistry Letters, 2010
- Preparation and Characterization of a Lecithin Nanoemulsion as a Topical Delivery SystemNanoscale Research Letters, 2009
- Perfluorocarbon Nanoemulsions for Quantitative Molecular Imaging and Targeted TherapeuticsAnnals of Biomedical Engineering, 2009
- Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulationsInternational Journal of Pharmaceutics, 2007