A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation
- 1 June 1987
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 327 (6124), 677-682
- https://doi.org/10.1038/327677a0
Abstract
A new T-cell receptor gene lies just 5' to the J alpha C alpha coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the gamma-chain in thymic subpopulations, making this a possible candidate for the recently described delta-chain of the T-cell receptor.Keywords
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