ADJUVANT POLYARTHRITIS .1. INCORPORATION OF QUANTITATIVE MEASUREMENTS OF HUMORAL AND CELLULAR IMMUNE-RESPONSE
- 1 January 1977
- journal article
- research article
- Vol. 201 (1), 1-7
Abstract
A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (mouse lymphoma EL4 cells) in the arthritic rat. Application of the new model system to mechanism studies is illustrated with cyclophosphamide. The drug is shown to suppress adjuvant arthritis by a combined anti-inflammatory and immunosuppressive action.This publication has 14 references indexed in Scilit:
- Effect of Sensitization to BSA on Adjuvant Disease in Normal and Neonatally Thymectomized Rats.Experimental Biology and Medicine, 1965
- ADJUVANT-INDUCED POLYARTHRITIS IN RATS - BIOLOGIC AND HISTOLOGIC BACKGROUND1965
- Studies on adjuvant‐induced polyarthritis in rats. III. The effect of “immunosuppressive agents” on arthritis and tuberculin hypersensitivityArthritis & Rheumatism, 1964
- PASSIVE TRANSFER OF ADJUVANT ARTHRITIS BY LYMPH NODE OR SPLEEN CELLSThe Journal of Experimental Medicine, 1964
- Inhibition by 6-Mercaptopurine of Polyarthritis induced by Freund's AdjuvantAnnals Of The Rheumatic Diseases, 1964
- Studies on adjuvant‐induced polyarthritis in rats. II. Histogenesis of joint and visceral lesionsArthritis & Rheumatism, 1963
- STUDIES OF ARTHRITIS AND OTHER LESIONS INDUCED IN RATS BY INJECTION OF MYCOBACTERIAL ADJUVANT .7. PATHOLOGIC DETAILS OF ARTHRITIS AND SPONDYLITIS1963
- Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory DrugsExperimental Biology and Medicine, 1962
- STUDIES OF ARTHRITIS AND OTHER LESIONS INDUCED IN RATS BY INJECTION OF MYCOBACTERIAL ADJUVANT .2. EVIDENCE THAT THE DISEASE IS A DISSEMINATED IMMUNOLOGIC RESPONSE TO EXOGENOUS ANTIGEN1960
- Development of Arthritis, Periarthritis and Periostitis in Rats Given Adjuvants.Experimental Biology and Medicine, 1956