The Inhibition of Granuloma Formation Around Schistosoma Mansoni Eggs
- 1 May 1967
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 16 (3), 284-292
- https://doi.org/10.4269/ajtmh.1967.16.284
Abstract
Summary It has been postulated that the granulomatous reaction of the host to the schistosome egg is a major factor in the development of hepatosplenic schistosomiasis, and that if this reaction were suppressed, no overt disease would develop. With a technique of injecting viable Schistosoma mansoni eggs into the lungs of mice, the effect on granuloma formation of five immunosuppressive drugs was investigated. The drugs, consisting of a steroid (fluocinolone acetonide), an inhibitor of DNA-mediated RNA synthesis (actinomycin D), a folic-acid antagonist (methotrexate), and two purine analogues (azathioprine and thioguanine), were administered for 32 days after egg injection; all of them suppressed granuloma formation to varying degrees. Whereas the peak average diameter of the granulomata in the control animals 16 days after injection of the eggs was 260% larger than that of the eggs themselves, in the animals treated with the steroid there was only a 36% increase in diameter. When the drugs were discontinued, the granulomata tended to increase in size, but never approached the peak levels in the control animals. The effects of prolonged administration and different dosage levels were also studied with several of the drugs.This publication has 11 references indexed in Scilit:
- Anemia in Mice Infected with Gamma-Irradiated or Nonirradiated Schistosoma MansoniThe American Journal of Tropical Medicine and Hygiene, 1965
- Repeated Infection and Treatment of Mice with Schistosoma mansoni: Functional, Anatomic and Immunologic ObservationsThe American Journal of Tropical Medicine and Hygiene, 1965
- A Comparative Study of Schistosoma mansoni Infections in Mice, Gerbils, Multimammate Rats and HamstersThe American Journal of Tropical Medicine and Hygiene, 1965
- Schistosomiasis in Parabiotic Mice. Histopathological Comparisons in Infected Mice and their Uninfected Partners *The American Journal of Tropical Medicine and Hygiene, 1965
- ACTINOMYCIN D EFFECT ON PRIMARY IMMUNE RESPONSE IN MICE - A HISTOLOGIC AND SEROLOGIC STUDY1965
- Comparison of Anti-Granuloma, Thymolytic and Glucocorticoid Activities of Anti-Inflammatory SteroidsExperimental Biology and Medicine, 1964
- Actinomycin D: Effect on the Immune ResponseScience, 1964
- The Contribution of Worm Burden and Host Response to the Development of Hepato-Splenic Schistosomiasis Mansoni in MiceThe American Journal of Tropical Medicine and Hygiene, 1963
- The Etiology of Hepato-Splenic Schistosomiasis Mansoni in MiceThe American Journal of Tropical Medicine and Hygiene, 1961
- Reduced Antibody Titers in Mice Treated with Carcinogenic and Cancer Chemotherapeutic AgentsExperimental Biology and Medicine, 1952