INDIUM-111-LABELED AUTOLOGOUS PLATELETS FOR LOCATION OF VASCULAR THROMBI IN HUMANS

Abstract

Patients (22) suspected of having either venous or arterial thrombi were studied with 111In-labeled autologous platelets. Whole-body scans were performed 3, 24 and 48 h following i.v. injection. Some twelve patients studied with saline-washed platelets had unsatisfactory 15 min recovery and biologic half-time. When the labeling was carried out in plasma, these values compared favorably with normal values reported for 51Cr-labeled autologous platelets. Of 10 patients studied using platelets labeled in plasma, 3 had normal scans, 6 had abnormal scans and 1 had an equivocal scan. All 6 abnormal scans were confirmed with corresponding positive findings in either the venogram, arteriogram or lung scan.